Macidol TR GAMMADOL Â® is a combination of ketorolac and tramadol which is an analgesic indicated for the short-term treatment of moderate to severe acute home (back pain, fractures, dislocations, sprains, cancer) in the treatment of postoperative pain, in the treatment of dental pain, migraine, headaches and the treatment of neuropathic pain. The pharmacology of oral combination analgesics rational therapy is for pain by different mechanisms of action, particularly an NSAID such as ketorolac and an opioid such as tramadol.
Ketorolac is a carboxylic acid pyrrolizine structurally related to indomethacin, Macidol TR belongs to the group of NSAIDs and has been used mainly for its analgesic activity. Tramadol is a centrally acting analgesic with two mechanisms of action that act synergistically to produce pain relief, compared with other opioids, has a low potential for abuse and dependence development. Both components of the formula is absorbed quickly and completely after oral administration.
- The recommended dose of tramadol is 50 to 100 mg (immediate release tablets) every 4 to 6 hours as needed for pain.
- The maximum dose is 400 mg/day.
- To improve tolerance patients should be started at 25 mg/day, and doses may be increased by 25 to 50 mg every 3 days to reach 50 to 100 mg/day every 4 to 6 hours.
- The recommended dose for extended release tablets is 100 mg daily, which may be increased by 100 mg every 5 days, but not to exceed 300 mg/day. To convert from immediate release to extended release, the total daily dose should be rounded down to the nearest 100 mg. Extended release tablets should be swallowed whole and not crushed or chewed.
- Tramadol may be taken with or without food.